PNNL Careers

Post Doctorate RA - Proteomics


Job Description

Job ID: 307991
Full/Part Time: Full-Time
Regular/Temporary: Temporary

Job Description

The Pacific Northwest National Laboratory (PNNL) is a multi-program laboratory operated by Battelle for the US DOE. The Chemical and Biological Signature Science Group (CBSS) is an interdisciplinary group of approximately 80 researchers who solve research and development problems related to chemical and biological detection and forensics. Much of the work involves trace detection in complex samples and is directed toward national security missions to prevent and counter acts of terrorism and the proliferation of weapons of mass destruction. Key challenges include: identifying appropriate signatures, sample collection/preservation and preparation, development of detection and analysis technologies, and development and validation of approaches and analytical methods for high confidence measurements.

CBSS is seeking a computationally oriented proteomics scientist with an interest in solving real-world problems in bioforensics and biosecurity. The successful candidate will contribute to research focused broadly on the identification and characterization of chemical signatures that are of concern to national security sponsors. The successful candidate will be a member of an inter-disciplinary team of scientists, engineers, and program managers and will be expected to build networks within and external to the CBSS group.

Responsibilities will include:
• Independently applying computational proteomics techniques to well defined assignments in a research and development laboratory
• Working in technical teams to complete well defined project tasks on time and within scope and budget
• Recommending technical approaches and making technical contributions that may ultimately affect the direction of the research
• Thoroughly documenting experiments and publishing data analysis methods

Equal Employment Opportunity

Battelle Memorial Institute (BMI) at Pacific Northwest National Laboratory (PNNL) is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All BMI staff must be able to demonstrate the legal right to work in the United States. BMI is an E-Verify employer. Learn more at

Minimum Qualifications

Candidates must have received a PhD within the past five years (60 months) or within the next 8 months from an accredited college or university.

Preferred Qualifications

• Demonstrated experience in computational and/or statistical aspects of proteomics and computational proteomics/proteomics data analysis
• Demonstrated experience in peptide and protein identification by database search; proficiency with one or more common proteomics database search engines (e.g., Mascot, MS-GF+, Sequest)
• Strong knowledge of one or more scripting languages (e.g., Python, R)
• Excellent oral and written communication skills
• Proteomics sample preparation laboratory experience is preferred
• Operation of liquid chromatography/mass spectrometry instrumentation is preferred
• Application of proteomics to microbial systems or protein toxins is preferred
• Experience in quantitative/comparative proteomics is preferred
• Experience in alternative peptide identification modes (spectral libraries, de novo peptide search) is preferred
• Experience managing multiple projects and tasks is preferred

Preferred Education: PhD in biology, chemistry, biochemistry, bioinformatics or a related field. Cumulative GPA of 3.25 or higher preferred.

Organization and Job ID

Job ID: 307991
Directorate: National Security
Division: Signatures Science & Technology
Group: Chemical & Biological Signature Science

Other Information

This position requires the ability to obtain and maintain a federal security clearance.

* U.S. Citizenship
* Background Investigation: Applicants selected will be subject to a Federal background investigation and must meet eligibility requirements for access to classified matter in accordance 10 CFR 710, Appendix B.
* Drug Testing: All Security Clearance (L or Q) positions will be considered by the Department of Energy to be Testing Designated Positions which means that they are subject to applicant, random, and for cause drug testing. In addition, applicants must be able to demonstrate non-use of illegal drugs, including marijuana, for the 12 consecutive months preceding completion of the requisite Questionnaire for National Security Positions (QNSP).

Note: Applicants will be considered ineligible for security clearance processing by the U.S. Department of Energy until non-use of illegal drugs, including marijuana, for 12 consecutive months can be demonstrated.